Curcumin could reduce the suppression of VEGF in an in vitro model of endometriosis [57] and block angiogenesis induced by hypoxia in vitro and downregulated VEGF expression [58]. In vivo, study found that curcumin inhibited angiogenesis through reducing microvessel density in Ehrlich ascites carcinoma-bearing mice; possible mechanism was proved to be inhibition of VEGF and VEGFR2 [59] and is able to inhibit tumor angiogenesis by the reduction of proangiogenesis factor VEGF in the Xenograft model of breast cancer [60]. The gene discussed is VEGFA; the disease is breast cancer.