BRCA1 and ovarian carcinoma: Biallelic mutations in BRCA1 (typically embryonically lethal) were identified in a patient with early onset ovarian cancer with hypersensitivity to platinum based treatment and therefore deemed a new subtype of Fanconi Anemia (FANCS) [41]. BRCA2 (FANCD1) was identified as a FA family member in 2002, following sequencing of BRCA1 and BRCA2 in cells from patients with FANCB and FANCD1 [42].