PDGFRA and diffuse intrinsic pontine glioma: Genetically engineered histone H3 K27M mutations in neonatal mice cooperate with activating platelet-derived growth factor receptor α (PDGFRα) mutant and Trp53 loss that may induce self-renewal of neural stem cell and develop diffuse intrinsic pontine glioma (DIPG) recapitulating human DIPG [56].