The 3-deazaneplanocin A (DZNep), a small molecule inhibitor of Ezh2, decreases global H3K27 trimethylation, and its overexpression is associated with aggressiveness of several cancers such as prostate, breast, and bladder, as well as melanoma (Bachmann et al., 2006; Clermont et al., 2017). The gene discussed is EZH2; the disease is melanoma.