PVT1 and nasopharyngeal carcinoma: We next assessed the effects of BAY 87-2243 on PVT1-mediated cell proliferation and colony formation, and found that this inhibitor markedly disrupted NPC cell proliferation and colony formation in KAT2AWT, but not KAT2AE570A/D601A, overexpressing NPC cells relative to EV controls (Fig. 6g, h).