Consistent with previous studies of HIF-1α mRNA stability [30], our data demonstrate that overexpression of KAT2A or TIF1β upregulate PVT1-mediated NF90 transcriptional activation in NPC cells in order to increase HIF-1α mRNA stability, while overexpression of KAT2A acetyltransferase activity-deficient mutants or TIF1β mutants lacking H3K9ac binding sites does not. Here, HIF1A is linked to nasopharyngeal carcinoma.