We first found that three histone acetyltransferases (KAT2A, KAT2B, and KAT8) were markedly upregulated and two (KAT5 and KAT6A) were markedly downregulated in three freshly frozen normal nasopharyngeal specimens relative to three clinical NPC tumors via RNA sequencing (≥1.5-fold, p < 0.05) (Supplementary Fig. 3A). Here, KAT2A is linked to nasopharyngeal carcinoma.