Moreover, as shown in Fig. 6c–e and Supplementary Fig. 4C, overexpression of KAT2AWT, but not KAT2AE570A/D601A, in HNE-1 NPC cells rescued PVT1 knockdown-mediated loss of HIF-1α expression, cell proliferation, and colony formation. The gene discussed is PVT1; the disease is nasopharyngeal carcinoma.