Moreover, we validated that both KAT2A and WDR5 protein expression levels were higher in NPC tissues compared with that in normal nasopharyngeal tissues (Supplementary Fig. 3C, D), but PVT1 knockdown had no effect on KAT2A or WDR5 expression (Supplementary Fig. 3E, F). This evidence concerns the gene PVT1 and nasopharyngeal carcinoma.