In this study, we identify a new putative mechanism by which the lncRNA PVT1 serves as a scaffold for the chromatin modification factor KAT2A, and thereby stabilizes HIF-1α via H3K9ac/TIF1β complex-mediated NF90 transcription in a manner critical for NPC tumorigenesis (Fig. 10). This evidence concerns the gene ILF3 and nasopharyngeal carcinoma.