As a consequence, considering the presence of erosions based on BMI category, the lowest plasma IL-6/IL-1RA ratio was found in overweight/obese naive RA without erosive disease than in normal weight naive RA with or without erosive disease and overweight/obese naive RA with erosive disease (p = 0.01 for all comparisons) (see Supplementary Fig. 1C). This evidence concerns the gene IL6 and rheumatoid arthritis.