CD68 and rheumatoid arthritis: Interestingly, IL-6 plasma levels, despite significantly reduced at the time of remission achievement compared to patients at diagnosis, directly correlates with the IHC score for sublining CD68+ cells only in overweight/obese RA in sustained clinical and ultrasound remission, supporting the notion that fat excess can promote IL-6 release, contributing to the persistence of residual synovial inflammation, despite good clinical response.