Considering the presence of bone damage, erosive naive RA showed higher IL-6 (66.6 ± 56.9 pg/ml) and IL-1RA plasma levels (789.5 ± 412.0 pg/ml) than no erosive patients (IL-6: 38.4 ± 54.3 pg/ml; p = 0.05 and IL-1RA: 571.1 ± 374.1 pg/ml; p = 0.04). The gene discussed is IL6; the disease is rheumatoid arthritis.