Moreover, considering the whole cohort of naive RA, BMI value directly correlated with the IHC scores for lining CD68+ (R = 0.24; p = 0.04), lining CD21+ (R = 0.36; p = 0.002) and sublining CD68+ (R = 0.39; p = 0.001) (Fig. 1N), sublining CD21+ (R = 0.37; p = 0.002), sublining CD20+ (R = 0.38; p = 0.001) and sublining CD3+ cells (R = 0.33; p = 0.005) respectively (Fig. 1O) and with the synovial aggregate grade (R = 0.33; p = 0.005) (Fig. 1P). The gene discussed is CR2; the disease is rheumatoid arthritis.