These findings are in line with MyD88 expression in ST of RA patients, directly correlating with BMI value regardless to RA phase and with the IHC scores of lining and sublining CD68+ cells in ST biopsies supporting the notion that an aberrant persistent over-expression of MyD88, dependent from fat mass excess, is involved in the promotion of residual synovitis persistence in ST of overweight/obese RA, despite sustained disease control. The gene discussed is CD68; the disease is rheumatoid arthritis.