Double immunohistochemistry showed that naïve RA with BMI ≥ 25 Kg/m2 showed significantly higher IHC score for sublining CD68+ (2.1 ± 0.8) (Fig. 1J), CD21+ (1.0 ± 1.1) (Fig. 1K) and CD20+ cells (1.9 ± 0.9) (Fig. 1L) compared to normal weight RA (1.5 ± 0.9 for CD68+ cells; p = 0.01; 0.5 ± 0.8 for CD21+ cells; p = 0.03; and 1.4 ± 0.8 for CD20+ cells; p = 0.05, respectively). The gene discussed is CR2; the disease is rheumatoid arthritis.