Moreover, despite we observed no differences at baseline in erosion score comparing overweight/obese and normal weight naïve to treatment RA patients, overweight/obese naive RA without erosive disease showed the lowest IL-6/IL-1RA ratio supporting the concept of an unbalance between pro-inflammatory and osteoclastogenic via OPG/RANK pathway, such as IL-629, and bone protective (as IL-1RA) soluble factors in naive RA based on BMI category. This evidence concerns the gene TNFRSF11A and rheumatoid arthritis.