Considering the whole RA cohort used for gene expression profile experiment, synovial tissue expression of MyD88 directly correlates with BMI value (R = 0.58, p = 0.02) and IHC scores for lining and sublining CD68+ cells (R = 0.59, p = 0.02 and R = 0.56, p = 0.03 for lining and sublining CD68+ cells respectively) in RA patients (Fig. 5H,I). This evidence concerns the gene MYD88 and rheumatoid arthritis.