Unlike miR-424-5p and miR-101-3p, higher expression of miR-128 and miR-139-5p, miR-382-5p and miR-410 was found to be significantly associated with worse survival outcome as well as various other tumor characteristics/marker/risk factor including the presence of tumor invasion, larger tumor size, multiple nodules, viral infection or higher AFP level (Fig. 4). The gene discussed is AFP; the disease is viral infectious disease.