Here we employed SLC-focused CRISPR knockout screens to identify two solute carriers, the CMP-sialic acid/CMP transporter SLC35A1/CST and the zinc transporter SLC30A1/ZnT1 as critical host factors affecting the survival of human cell lines towards infection with the oncolytic VSV virus in opposite ways (Fig. 1). This evidence concerns the gene SLC35A1 and infection.