These methods provide information about molecular alterations due to point mutations, including tumor-specific mutations, and have been used as diagnostic, prognostic, and therapeutic decision-making tools, especially in lung cancer (to detect epidermal growth factor receptor [EGFR] and Kirsten rat sarcoma viral oncogene homolog [KRAS] mutations) and colorectal cancer (to detect RAS mutations)8–10. The gene discussed is KRAS; the disease is colorectal cancer.