In another study, Cabello et al. 50 tested the effect of cytokinins and cytokinin nucleosides in various human cancer cell lines and observed that the accumulation of DNA damage was associated with rapid upregulation of DNA damage associated genes, e.g. CDKN1A (CYCLIN DEPENDENT KINASE INHIBITOR 1A) or GADD153 (GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN). The gene discussed is CDKN1A; the disease is cancer.