As expected, pro-apoptotic Bax expression was upregulated in vehicle-treated animals in response to ischemia compared to sham; however, IRL-1620 treatment significantly attenuated the ischemia-induced increase in Bax expression (P < 0.001) at 7 h, 24 h and day 7 post MCAO (Fig. 2B). The gene discussed is BAX; the disease is ischemia.