Most of the samples with chromosome 5p–12q translocations were oral mucosal melanomas (7 oral, 1 anorectal), of East Asian ancestry (7 East Asian, 1 European), had amplifications of CDK4 or MDM2 (7/8) on chromosome 12 and TERT or SKP2 (4/8) on chromosome 5 and were, on average, younger at tumor diagnosis when compared with the overall cohort (P = 0.006, mean age 42 vs 58). This evidence concerns the gene SKP2 and mucosal melanoma.