These amplified loci encompassed known melanoma drivers TERT (chr5), CCND1 (chr11), MDM2 (chr12), and CDK4 (chr12)7,18 (Supplementary Fig. 3d–f), as well as other genes reported to be amplified and/or overexpressed in melanoma19,20 including SKP2 (chr5) and GAB2 (chr11). The gene discussed is MDM2; the disease is melanoma.