MDM2 and melanoma: This analysis revealed strong similarities with melanomas of cutaneous (including acral) sites, with frequent targeting of TERT, CCND1, KIT, MITF, CCND1, MDM2, CDK4, and NOTCH2 by amplification (Fig. 4c, d), and copy loss of NF1, PTEN, CDKN2A, ATM, and ARID1B (Fig. 4c, e).