Interestingly, several of the L1-regulated genes have previously been implicated in neurodevelopmental disorders such as autism (CDH8, GABRR1, MET)31–33, cognitive impairment (SYT1, TUSC3, TBCK)34,35, and epilepsy (PLCB1)36. The gene discussed is SYT1; the disease is neurodevelopmental disorder.