Functionally, WWP1 has been postulated to function as an oncogenic factor by regulating the stability of several cancer-related proteins, such as p53, p63, KLF2, JunB, HER4, and KLF5, and its dysregulation has been implicated in cancers, infectious diseases, neurological diseases, and ageing9,10,15. This evidence concerns the gene KLF2 and cancer.