Interestingly, though IKZF1 was mainly expressed in lymphocytes and was downregulated in CRC tumor tissues (Supplementary Fig. 12A), single cell RNA-Seq data20 suggested that it was also highly expressed in 4.0% of tumor cells (FPKM > 5) and in none of the normal mucosa cells (Fisher’s exact test P = 0.009, Supplementary Fig. 12B). The gene discussed is IKZF1; the disease is neoplasm.