The expression of the PRKCSH gene was significantly upregulated in various cancer tissues such as glioblastoma multiforme, esophageal carcinoma, lymphoid neoplasm diffuse large B-cell lymphoma, thymoma, liver hepatocellular carcinoma, pancreatic adenocarcinoma, stomach adenocarcinoma, and skin cutaneous melanoma ((Fig. 1a, b; Supplementary Fig. 1a). The gene discussed is PRKCSH; the disease is cutaneous melanoma.