Interestingly, GO analysis of common downregulated genes upon NIPBL or BRD4 depletion showed enrichment in categories such as ion transport, central nervous system development, chondrocyte differentiation, regulation of ossification, hair follicle development, axon guidance, and cell proliferation (Fig. 3c), which are potentially related to many of the observed traits of CdLS probands (i. This evidence concerns the gene NIPBL and Cornelia de Lange syndrome.