Anwar et al.29 analyzed MEG3 expression in a series of 34 human HCC specimens and observed that 20 HCC samples displayed downregulation of MEG3. More interestingly, a significant correlation between MEG3-DMR methylation and reduction of MEG3 expression was established in these samples, which was consistent with our observations. The gene discussed is MEG3; the disease is hepatocellular carcinoma.