In this study, we highlighted an interconnection between two epigenetically controlled miRNAs located in two distinct imprinted loci: (1) MEG3-derived miR-493-5p, which was silenced through MEG3-DMR hypermethylation in liver cancer cells and tumors from patients, and (2) IGF2-derived intronic miR-483-3p, which was overexpressed in hepatic cell lines exhibiting IGF2 LOI. Here, MEG3 is linked to liver cancer.