HNRNPL and colorectal carcinoma: This function of hnRNP L is inferred to be universal since enhanced DSB signals were observed in both CIT-stimulated CH12F3-2A cells and in oxaliplatin-treated CRC cells with depleted hnRNP L. We demonstrated that knockdown of hnRNP L significantly increased the sensitivity of all four examined CRC cell lines to oxaliplatin.