MBNL2 belongs to the Muscleblind-like family and contributes to myotonic dystrophies type 1 and 2 (DM1 ad DM2) and expresses in the hippocampus and MBNL2 knockouts show a decrease in N-methyl-D-aspartic acid receptor (NMDAR) synaptic transmission and impaired hippocampal synaptic plasticity. This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.