In summary, the miR-30 family can regulate autophagy, apoptosis, oxidative stress, and inflammation by targeting XBP1, TGF-β1, CTGF, and other mRNAs, which are involved in the pathogenesis of VR associated with different diseases such as IHD, HHD, DCM, antineoplastic drug CTX, and other CVDs (Figure 1). Here, XBP1 is linked to familial dilated cardiomyopathy.