Although there is no direct evidence to link TCA cycle dysfunction with alterations in JHDM activity in NAFLD, in a mouse model, hepatic steatosis occurred in association with altered JHDM expression and altered H3K4 and H3K9 trimethylation at the peroxisome proliferator-activated receptor alpha (PPARα) gene and in a number of other genes important in lipid catabolism [88]. Here, PPARA is linked to metabolic dysfunction-associated steatotic liver disease.