D-dimer, plasmin, TFPI, and TF all performed well in distinguishing ALN from healthy controls (AUC = 0.71 p < 0.001, AUC = 0.94 p < 0.0001, AUC = 0.75 p < 0.0001, AUC = 0.66 p < 0.01, respectively, as is also shown in Fig. 3), as well as from CKD patients (AUC = 0.63 p < 0.05, AUC = 0.68 p < 0.01, AUC = 0.70 p < 0.001, AUC = 0.62, p < 0.05, as shown in Fig. 3). Here, PLG is linked to chronic kidney disease.