The influence of increased IFN-β production on canonical ISGs, MX1 (Fig. 2i) and IFIT1 (Fig. 2j), also revealed viral differences as MEKi further enhanced expression of RV2-induced MX1 and IFIT1 mRNA compared to RV2 alone (3.6-fold, p < 0.05,3.7-fold, p < 0.05, respectively) while there was no enhancement effect following RSVA2 infection (Fig. 2i and j). This evidence concerns the gene IFIT1 and infection.