More importantly, by immunohistochemistry (IHC) staining of tumor tissues from xenograft models with either CK18 (Fig. 5c) or αV-integrin (Fig. 5d) we were able to detect LO-like structures ranging 2–5 μm in size (see arrows in 60× panels, Fig. 5c and d). Here, KRT18 is linked to neoplasm.