Among LOR80 protein cargo, we also found uPAR, another protein differentially expressed in DU145R80 cells compared to DU145 [17], with pivotal role in cancer adhesion, invasion and metastasis, related to its proteolytic activity as well as to the capacity to trigger changes in cell morphology, migration and signaling, by interacting with several molecular partners, including integrins [32–35]. This evidence concerns the gene PLAUR and cancer.