Notably, uPAR has been related with PCa aggressiveness [17, 36] and its interaction with integrins has been previously described to control plasticity of PCa cell movement in both mesenchymal and amoeboid migration style [37], in line with the peculiar mesenchymal phenotype of DU145R80 we have previously described [14], as well as with blebbing, a typical amoeboid feature [38, 39]. This evidence concerns the gene PLAUR and posterior cortical atrophy.