CCND1 and hepatocellular carcinoma: Consist with previous studies, our experiment also showed that after 24 h of sorafenib treatment, levels of β-catenin and its downstream target genes including c-Myc and CyclinD1 were upregulated in SMMC-7721, MHCC-97H, and SK-Hep1 HCC cell lines (Additional file 1: Figure S1a).