KRAS and non-small cell lung carcinoma: Isotopic profiling experiments using 13C-glucose and/or 13C-glutamine performed in vivo in mouse KRAS-driven NSCLC and directly in patients using intraoperative 13C-glucose infusions revealed NSCLC tumors rely much more on glucose than on glutamine for TCA cycle anaplerosis in vivo [93, 94, 202].