BCL2 and acute myeloid leukemia: For example, statins also enhanced ABT-199 efficacy in AML through the inhibition of protein geranyl-geranylation, which leads to BCL2 modulation and upregulation of pro-apoptotic BH3 only proteins PUMA [132] and etomoxir, increasing the therapeutic efficacy of ABT-737 in vivo [43].