Given the crucial roles of wild type IDH1/2 in cell metabolism (e.g. Krebs cycle, OxPHOS, cytosolic and mitochondrial redox, anabolism including lipid biosynthesis), a better understanding of the contribution of oncogenic IDH mutations to AML cell intermediary metabolism and α-KG homeostasis is expected to lead to new therapeutic strategies. Here, IDH2 is linked to acute myeloid leukemia.