Coherent exposition to SRT2183 provoked a prominent decrease in G1 phase-related protein such as Cyclin D1 and pRb in LN229 and U87MG cell lines (Fig. 2b, upper panel), accompanied by a decrease in ki67 staining in SRT2183-treated glioma cells (Fig. 2b, lower panel). The gene discussed is CCND1; the disease is central nervous system cancer.