Coherent exposition to SRT2183 provoked a prominent decrease in G1 phase-related protein such as Cyclin D1 and pRb in LN229 and U87MG cell lines (Fig. 2b, upper panel), accompanied by a decrease in ki67 staining in SRT2183-treated glioma cells (Fig. 2b, lower panel). Here, RB1 is linked to central nervous system cancer.