To our knowledge, this is the most comprehensive meta-analysis to date on associations between TLR gene polymorphisms and TB, and our combined analyses suggested that TLR1 rs4833095, TLR1 rs5743557, TLR1 rs5743596, TLR1 rs5743618, TLR2 rs3804099, TLR2 rs5743704, TLR2 rs5743708, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810 and TLR8 rs3764879 polymorphisms were all significantly associated with TB in certain ethnicities. The gene discussed is TLR4; the disease is tuberculosis.