These factors were the following: male status, larger primary tumor size (T2–T4), lymph node metastasis, advanced stage (II–IV) (in the whole study cohort, in the group of non-smoking and smoking patients, in AC and SCC); age ≥60 years (whole cohort, smoking), higher G status (SCC); smoking status (whole cohort, AC); high expression of EGFR (AC). This evidence concerns the gene EGFR and metastatic malignant neoplasm in the lymph nodes.