Intriguingly, blocking NKG2D and TRAIL on NK cells, as well as TRAIL-R2 on GBM cells after treatment with 12.5 nM BTZ, rescued the cells from NK cell lysis more significantly (all p < 0.01, Figure 3A,B,D–F), where isotype control had no effect (p > 0.05, Figure 3A,C). The gene discussed is TNFRSF10B; the disease is glioblastoma.