Vasopressin increases the renal reabsorption of solute-free water back into the circulation and V2r-deficient mice showed increased water intake and increased urine output (Diabetes insipidus) [35]; however, daily (24 h) urine amounts and water intakes were indistinguishable between virgin adult WT and Cth−/− female mice (5.38 ± 1.12 and 4.83 ± 0.67 g per 20 g body weight for urine amounts; 6.48 ± 1.81 and 5.77 ± 0.89 g per 20 g body weight for water intake, respectively). Here, CTH is linked to Central diabetes insipidus.