This I2-mediated response, which was observed in individual tumor samples, also agreed with our transcriptomic analysis results in which the primarily upregulated pathways corresponded to cell differentiation and cell adhesion molecules (CAM), whereas the downregulated pathways corresponded to invasive potential (ECM-receptor interaction), survival/antiapoptotic pathways (P13K-AKT), and chemoresistance (drug metabolism). This evidence concerns the gene AKT1 and neoplasm.