For instance, it was reported that mutant p53 that is co-expressed with WT p53 in human bronchial epithelial cells inhibits the response of the cancer cells to transforming growth factor β1 (TGF-β1), thus suggesting a possible dominant-negative effect of mutant p53 over WT p53 (Gerwin et al., 1992). The gene discussed is TP53; the disease is cancer.