Moreover, to study whether GLK+IL-17A+ T-cell population is a useful diagnostic biomarker for active SLE (SLEDAI ≧ 12), the diagnostic utility of the frequencies of GLK+IL-17A+ T-cell subsets were analyzed by liner regression and ROC curve analyses (Fig. 1F, G). This evidence concerns the gene MAP4K3 and systemic lupus erythematosus.