Similarly, we assessed the expression of TRIB2 and MAP3K1 in glioma/GBM by analyzing the TCGA (RNA sequencing) database, and the results demonstrated that TRIB2 and MAP3K1 were markedly increased in glioma tissues, especially GBM tissues, compared with nontumor tissues (Figure 4A,B). Here, MAP3K1 is linked to central nervous system cancer.