HNF4A and neoplasm: Moreover, Wnt/TCF signaling‐dependent activation of TRIB2 stimulates the proliferation of liver cancer cells through a stabilization effect on yes‐associated protein (YAP).10 Hou et al7 found that TRIB2 increases colorectal cancer tumor growth by decreasing the expression of p21, which functions as a tumor suppressor gene, indicating that TRIB2 could become a potential molecular target for colorectal cancer.