MAP3K1 and central nervous system cancer: The results indicated that the AUCs of TRIB2 and MAP3K1 were 0.822 (P < 0.01) and 0.855 (P < 0.01), respectively, and the AUC of the WHO classification of glioma was 0.789 (P = 0.000002), indicating that combined increases in TRIB2 and MAP3K1 are associated with significant sensitivity and specificity for the prediction of a poor prognosis in patients with glioma (Figure 7F and Table 5).