HTT and Huntington disease: The mutant Htt causes selective neuronal loss in the brain, particularly in the striatum and cortex.6 The PKC family consists of many isoforms and plays a vital role in regulating neuronal survival, proliferation, differentiation and apoptosis.7, 8 PKC mRNA levels decrease in the brain of R6/2 transgenic HD mouse model and patients with HD.9, 10 PKC inhibition causes severe neuron death in HD Q111 transgenic mice.11 Therefore, activating PKC pathway may be a potential method to treat HD.