DKK1 and renal fibrosis: DKK1 inhibits mitochondrial dysfunction, cellular senescence, and renal fibrosis even in an established disease state (Figure 6), and ICG‐001 protects mitochondrial biogenesis and cell proliferation ability (Figure 8), suggesting that inhibition of Wnt/β‐catenin could be of great value in protection against age‐related mitochondrial dysfunction and renal fibrosis.