HAVCR2 and nasopharyngeal carcinoma: In addition to the reported effect of FasL+ MHC‐I+ TDEs to induce CD8+ T‐cell apoptosis, a more recent study has reported that TDEs that express MHC‐II and galectin‐9, a ligand of the death receptor Tim‐3, are detectable in the plasma of patients with nasopharyngeal carcinoma, and can induce apoptosis in mature Th1 lymphocytes (Figure 2).153 This effect was inhibited by both anti‐Tim‐3 and anti‐galectin‐9 antibodies.