One study found that when cancer cells were engineered to express the same antigen on their cell surface, on their exosomes, or in a secreted form, the cells expressing the antigen on their exosomes induced a stronger antigen‐specific in vivo immune response.129 These TDEs were found to induce multiple antitumor immune responses, including antigen‐specific CD8+ T‐cell responses, CD4+ T‐cell help, antigen‐specific antibodies, and a decrease in the tumor abundance of Tregs. The gene discussed is CD8A; the disease is neoplasm.