HLA-G and melanoma: HLA‐G, a potent suppressive molecule that impairs effector functions of immune cells, has been detected in TDEs from a melanoma cell line,122 and ascites and pleural exudates derived from cancer patients.170 A recent study has demonstrated that TDEs derived from renal CSCs vs non‐CSCs, are the major mediator of an inhibitory effect on monocyte differentiation and maturation to DCs171 (Figure 3), and that this effect was mediated by HLA‐G+ TDEs.