In another study of mesothelioma patients, downregulation of NK group 2D (NKG2D) activating receptor expression on CD8+ T‐cells and NK cells was found to partly rely on TDEs carrying MHC‐I‐related NKG2D and killer cell immunoglobulin‐like receptor 2D (KIR2D) ligands, such as the human leucocyte antigen (HLA)‐G class.156 HLA‐G is a nonclassical HLA class I molecule, and can potently suppress the effector functions of immune cells of the innate and adaptive immune system. Here, KLRK1 is linked to mesothelioma.