Although the underlying mechanisms responsible for HSP release remain to be elucidated, heat‐stressed TDEs enriched in HSPs may be an efficient means to induce immune responses in vaccines intended for tumor immunotherapy.135 TDEs are a source of multiple tumor antigens and can be engineered to redirect their effects on immune cells to elicit or augment DC‐mediated immunotherapy approaches designed to promote CTL and NK cell cytolytic immune responses. The gene discussed is HSP90B2P; the disease is neoplasm.