When TDEs are loaded onto human DC cells, TDEs bearing MHC‐I proteins and the lysosome‐associated membrane protein‐1 were found to transfer tumor antigens, and to induce antigen‐specific CTL activation responses in vitro and induce CD8+ T cell‐dependent antitumor effects in a mouse tumor model.110 In the same study, TDEs derived from different cancer cell lines were found to induce cross‐protective immune responses, indicating that TDEs may contain shared tumor‐rejection antigens that can induce antigen‐specific immune responses independent of the tumor MHC type match. The gene discussed is CD8A; the disease is cancer.