HLA‐G binding to KIR2D on NK also inhibits the cytolytic function of these cells (Figure 2).162 TDEs isolated from the plasma of patients with advanced melanoma skew CD14+ monocyte differentiation toward CD14+HLA‐DR−/low cells that demonstrate TGF‐β‐mediated suppressor activity on T‐cell functions. This evidence concerns the gene CD14 and melanoma.