TBI has been reported to be an important risk factor for several tauopathies.1–3 Experimental models and human cases have shown formation of tau aggregates after a moderate to severe TBI; however, the exact linkage to deposition of pathological tau and disease remains to be elucidated.19 In this study, young P301S mice subjected to TBI were analyzed at short and long time points after the impact, and brains were assessed for tau aggregation and spreading. The gene discussed is MAPT; the disease is tauopathy.