Neuropathological Braak staging of tau accumulation in AD progresses from transentorhinal/locus coeruleus (stages I/II), limbic (stages III/IV), and isocortical (stages V/VI).6–8 In CTE, tau is found around small vessels at the depths of sulci in the cerebral cortex (stage I), superficial layers of adjacent cortex (stage II), frontal, insular, temporal and parietal cortices, and amygdala, hippocampus, and entorhinal cortex (stage III), and finally ptau pathology is found widespread in the entire brain (stage IV).9 This evidence concerns the gene MAPT and Alzheimer disease.