Abnormal phosphorylation, however, triggers microtubule-bound tau to be released.1,2 Hyperphosphorylated tau (ptau) aggregates generate neurofibrillary tangles (NFTs) that are considered the pathological hallmark of tauopathies including Alzheimer disease (AD), chronic traumatic encephalopathy (CTE), and frontal-temporal dementia (FTD), among others.2–5. The gene discussed is MAPT; the disease is Alzheimer disease.