Lung adenocarcinoma is a major contributor to cancer‐related death all over the world.3 LncRNAs are considered as biomarkers as well as molecular targets for cancer therapies.18 In this study, we investigated the role of lncRNA H19 and CDH1, methylation of CDH1 in lung adenocarcinoma and found that in contrary to CDH1, lncRNA H19 and methylation of CDH1 played a positive role in the pathological process of lung adenocarcinoma. Here, CDH1 is linked to lung adenocarcinoma.