We speculate that sialylation of cell surface glycoproteins may regulate cell adhesion in lymphoma, and desialylation by neuraminidase or knockdown of ST6Gal1 may enhance cell adhesion to galectin or extracellular matrix, thereby inhibiting the invasiveness or metastasis of lymphoma cells and providing a potential strategy for lymphoma glycotherapy by desialylation. This evidence concerns the gene ST6GAL1 and lymphoma.