GNE and neoplasm: Knockdown of GNE in HBL‐8 3G3 cells appears to inhibit cell growth and enhance cell death caused by ceramide, an inducer of apoptosis or cell death.11 The survival of tumor cells from stress such as hypoxia, oxidative stress, or apoptosis may be related to increased metastatic tumors, and thus the high survival rate of 3G3 clone cells following sialylation may be associated with high metastasis in a SCID animal model.