Recent research has shown that IgM signaling helps drive lymphoma development.23 IgM signaling stimulated multidirectional signals, such as CD79a, CD79b, Lck/Yes novel tyrosine kinase (LYN), spleen tyrosine kinase (SYK), Bruton's kinase (BTK), caspase recruitment domain‐containing protein 11 (CARD11), and PI3K‐Akt. The gene discussed is CD40LG; the disease is lymphoma.