IgM signaling works in conjunction with the CD40‐CD40L system in B cells.20 It was previously reported that N‐glycans on immunoglobulin in follicular lymphoma may regulate cell growth by interacting with dendritic cell‐specific intracellular adhesion molecule 3‐grabbing non‐integrin (DC‐SIGN) lectin.21 It was also reported that galectin‐1 expressed in stromal cells induces IgM signaling by interacting with the glycans of IgM.22 These studies suggest that interactions between N‐glycans and lectins in hematopoietic cells may help regulate cell growth and/or adhesion. This evidence concerns the gene CD40LG and follicular lymphoma.