SIRT1 and ovarian carcinoma: By creating ovarian carcinoma cell lines overexpressing wild-type SIRT1 and NLS mutated SIRT1 and performing Transwell assays, we found that the overexpression of wild-type SIRT1 significantly increased cell motility, while the overexpression of SIRT1NLSmt markedly decreased cell motility compared with the cell motility observed in the Con136 cells.