SIRT1 and neoplasm: The results of proteomic approaches and Transwell assays demonstrated that the cytoplasmic localization of SIRT1 might suppress the mesenchymal program, activate the epithelial program, and inhibit the migration and invasion of ovarian carcinoma cells, thus providing experimental evidence showing that the role of SIRT1 as a tumor suppressor or oncogene may depend on its subcellular localization as follows: SIRT1 may suppress tumor progression when it is located in the cytoplasm or function as an oncogene when it is located in the nucleus.