Loss of EZH2 and mitotic activity at the invasion front of colon cancer seems to play an important role for the acquisition of mesenchymal characteristics that are required for the migration and invasion of disseminating tumor and cancer stem cells (Palmqvist et al. 1998, 1999, 2000; Jung et al. 2001; Jie et al. 2007). This evidence concerns the gene EZH2 and malignant colon neoplasm.