EZH2 and neoplasm: Besides its functional role for cell cycle regulation, EZH2 is also involved in metastasis by modulating tumor angiogenesis and the epithelial-to-mesenchymal transition, a process by which disseminating tumor cells acquire mesenchymal characteristics to migrate through the extracellular matrix (Simon and Lange 2008; Kim and Roberts 2016; Crea et al. 2012).