Low concentrations of Chm-1 appear to promote osteoblastic-cell growth, whereas higher concentrations of Chm-1 suppressed the growth and migration of tumour cells, such as human cervical cancer (HeLa) cells and human neuroblastoma (SH-SY5Y) cells, and inhibited the proliferation and angiogenesis of human umbilical vein endothelial cells (HUVECs) [49]. This evidence concerns the gene CNMD and neoplasm.