HSPA5 and nasopharyngeal carcinoma: Mechanistic studies revealed that Chm-1 can induce human nasopharyngeal carcinoma (NPC) cell apoptosis by inhibiting the formation of the cell surface-associated endoplasmic reticulum chaperone glucose-regulated protein 78 (GRP78)-phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signalling complex [52].