Interestingly, it has also been shown that, in glioblastoma stem-like cells (GSCs), the m6A demethylase ALKBH5 is highly expressed, and the depletion of ALKBH5 and FOXM1-AS disrupts GSC tumorigenesis through the reduction FOXM1 expression (Zhang et al., 2017) (Figure 2A). This evidence concerns the gene ALKBH5 and glioblastoma.