Pharmacological inhibition of PADs, using Cl-amidine or a PAD2/PAD4 inhibitor has also been shown to improve survival in several murine models of sepsis and LPS-induced endotoxemia (Zhao et al., 2016; Biron et al., 2017; Liang et al., 2018). Here, PADI2 is linked to serum lipopolysaccharide activity.