Five mammalian PAD isozymes have been identified which participate in physiological and pathophysiological processes, including autoimmune and neurodegenerative diseases, cancer and sepsis (Wang and Wang, 2013; Witalison et al., 2015; Kosgodage et al., 2017, 2018; Lange et al., 2017; Biron et al., 2018; Costa et al., 2018). The gene discussed is PADI4; the disease is Sepsis.