We discovered that a number of patients with focal epilepsy with either unknown cause or MTS showed various neuronal antibodies, GABA antibodies being the most common in 11 (33.3%), followed by NMDA-R in 2 (6.1%), GAD in 1 (3.0%), APL in 1 (3.0%), CV2 in 1 (3.0%), Tr in 1 (3.0%), recoverin in 1 (3.0%), and dsDNA in 1 (3.0%) of the patients. The gene discussed is RCVRN; the disease is focal epilepsy.