LATS2 and non-small cell lung carcinoma: Given that LATS2 is an upstream regulator of YAP in the Hippo pathway, we summarize a positive feedback loop pathway in NSCLC (Figure 6); miR-25 overexpression, induced by oxidative stress in NSCLC, inhibits LATS2 expression, which reduces the phosphorylation of YAP, promoting the translocation of YAP oncoprotein from the cytoplasm to the nucleus.