Among the therapies proposed for CRC, anti-epidermal growth factor receptor (EGFR) mAb therapy is not indicated for carriers of RAS mutations [approximately 50% of patients with metastatic CRC because the mutations in the RAS gene (mainly in exons 2, 3, and 4 of KRAS and NRAS) make metastatic CRC patients non responders to anti-EGFRs mAB treatment] (Boleij et al., 2016). This evidence concerns the gene EGFR and colorectal carcinoma.