A possible flaw of this test is that Epi proColon® detected the methylated status of the same region of the SEPT9 gene in some patients affected by other cancers (i.e., prostate, breast, lung or other diseases, hypertension, hyperlipidemia, diverticulitis, chronic gastritis, or cardiovascular) and according to their age (Ørntoft et al., 2015). This evidence concerns the gene SEPTIN9 and cancer.